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To elucidate possible mode of action (MOA) and human relevance of hepatotumorigenicity in rats for ethyl tertiary-butyl ether (ETBE), male F344 rats were administered ETBE at doses of 0, 150 and 1000mg/kg body weight twice a day by gavage for 1 and 2weeks. For comparison, non-genotoxic carcinogen phenobarbital (PB) was applied at a dose of 500ppm in diet. Significant increase of P450 total content...
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