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In this issue, Hellmann‐Regen et al. suggested that anti‐acne effects of erythromycin and tetracyclines may be related to their inhibitory effect of cytochrome P450‐mediated degradation of all‐trans‐retinoic acid (ATRA). We have recently proposed that all anti‐acne agents function by attenuation of increased mTORC1 signalling. This commentary links the P450 system to mTORC1 regulation in acne. Drug‐mediated...
Acne in adolescents of developed countries is an epidemic skin disease and has currently been linked to the Western diet (WD). It is the intention of this viewpoint to discuss the possible impact of WD‐mediated nutrient signalling in the pathogenesis of acne. High glycaemic load and dairy protein consumption both increase insulin/insulin‐like growth factor‐1 (IGF‐1) signalling (IIS) that is superimposed...
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