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Rats from two different strains, i.e. Wistar rats and Lister hooded rats, were investigated for their ability to acquire the kindling syndrome. After having received 13 kindling stimulations (injection of pentylenetetrazol), the animals were tested for subsequent alterations in induction and maintenance of hippocampal long-term potentiation (LTP) and, moreover in glutamate binding. It was found that...
We have studied the role of the N-methyl-D-aspartate (NMDA)/R1 receptor subunit in the mechanism of long-term potentiation (LTP) using an antisense-oligodeoxynucleotide strategy. Antisense-oligodeoxynucleotide (aDON; 10 nmol) or sense-oligodeoxy-nucleotide (sDON) were applied into the right ventricle of 7 week old male Wistar rats every 12 h for 3 days. Thereafter, in hippocampal slices extracellular...
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