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Ethyl shikimate is the first intermediate in the synthesis of oseltamivir phosphate (Tamiflu). Commercially, it is synthesised from the esterification of (−)-shikimic acid with ethanol in the presence of SOCl2 in batch. Herein is a comprehensive study on the continuous flow synthesis of ethyl shikimate in >90% yield and less than 10 min residence time. Furthermore due to environmental, health and...
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