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Exploring how risk genes cumulatively impair brain function in preclinical phase (i.e., in cognitively normal elderly) could provide critical insights into the pathophysiology of Alzheimer's disease (AD). Working memory impairment has always been a considerable cognitive deficit in AD, which is likely under complex genetic control. Though, the APOE ɛ4 allele could damage the working memory performance...
A model for encoding and the retrieve of the sequential working memory is proposed by using bidirectional inhibition-connected neural networks with winnerless competition. It is found that the retrieve accuracy is dependent on the encoding time the the properties of the neural inhibition weights. The simulation results shows the effectiveness of our proposed model.
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