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Th17 and γδ T cells are the dominant IL‐17‐producing cell. We previously reported that high‐mobility group box 1 (HMGB1) is critical in inducing IL‐17‐producing alloreactive T cells during early stage of acute allograft rejection. However, the role of γδ T cells during this process and its implication in HMGB1–mediated allograft rejection are not fully understood. Here, we use a murine model of cardiac...
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