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Objective: Aberrant activation of Hedgehog signalling pathway is involved in the progression of various human tumours, such as gastric cancer, paediatric brain tumour and hepatocellular carcinoma. However, the correlation of this signalling with tumourigenesis and patients' survival of gliomas has not been well documented. The present study was undertaken to examine the expression of Hedgehog signalling...
Matrix metalloproteinases (MMPs) have been proposed to be involved in remodeling the tumor–stromal microenvironment. The protease-activated receptors (PARs) are the latest MMP targets. Recent studies have revealed that stromal-derived MMP-1 acts as a signaling molecule by cleaving PAR1 to cause tumor migration and invasion of various cancers. However, the involvement of MMP-1/PAR1 signaling pathway...
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