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Front Cover: In article number 1900425, Hyun Jeong Oh, Seok Chung and co‐workers reconstituted the 3D brain endothelial barrier in a microfluidic device with a hydrogel scaffold. The developed platform provides quantitative evaluation of the efficacy of cell‐penetrating peptide (CPP) utilizing receptor‐mediated transcytosis by various assays. The specific/non‐specific transcytosis of CPP in the microfluidic...
In drug delivery to the human brain, blood vessels are a significant hurdle because they restrict the entry of most solutes to protect brain. To overcome this hurdle, an in vitro 3D model for brain endothelial barrier is developed using a microfluidic device with hydrogel providing a 3D extracellular matrix scaffold. Using the model, peptides known to utilize receptor‐mediated transcytosis are verified,...
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