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Synphilin-1 is a novel α-synuclein interacting protein presenting in the Lewy bodies, the N-terminal 12 residues peptide of α-synuclein (α-syn12) can binding to the coiled-coil domain of Synphilin-1. However, the complex structure in water has not been determined by experimental methods, so that the possible structure of this complex and interaction sites have been studied by docking algorithms and...
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