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Objectives
Tumour necrosis factor alpha (TNF‐α) expressed by nucleus pulposus cells (NPCs) plays a critical role in intervertebral disc (IVD) degeneration. A key unfolded protein response (UPR) component, X‐box binding protein 1 (XBP1) and nuclear factor‐kappa B (NF‐κB) are essential for cell survival and proliferation. The aim of our study was to elucidate the roles of XBP1 and NF‐κB in IVD degeneration...
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