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Chemodynamic therapy (CDT) utilizes Fenton or Fenton‐like reactions to convert hydrogen peroxide (H2O2) into cytotoxic hydroxyl radicals (•OH) and draws extensive interest in tumor therapy. Nevertheless, high concentrations of glutathione (GSH) and insufficient endogenous H2O2 often cause unsatisfactory therapeutic efficacy. Herein, a GSH‐depleting and H2O2 self‐providing carrier‐free nanomedicine...
Poor selectivity and unintended toxicity to normal organs are major challenges in calcium ion (Ca2+) overload tumor therapy. To address this issue, a cell membrane‐anchoring nano‐photosensitizer (CMA‐nPS) is constructed for inducing tumor‐specific Ca2+ overload through multistage endogenous Ca2+ homeostasis disruption under light guidance, i.e., the extracellular Ca2+ influx caused by cell membrane...
Tumor Therapy
In article number 2204689, Xiaoqing Yi, Gengyun Sun, Xiaoyan He, and co‐workers develop a cell membrane‐anchoring nano‐photosensitizer (CMA‐nPS) based on genetically engineered cellular membrane vesicles. The nano‐photosensitizer significantly induces intercellular Ca2+ overload through multistage endogenous homeostasis disruption under laser irradiation. With an obvious synergistic...
Ni‐rich layered oxides are significantly promising cathode materials for commercial high‐energy‐density lithium‐ion batteries. However, their major bottlenecks limiting their widespread applications are capacity fading and safety concerns caused by their inherently unstable crystal structure and highly reactive surface. Herein, surface structure and bulk charge regulation are concurrently achieved...
A hydrogen (H2) gas sensor based on a silicon (Si) nanomesh structure decorated with palladium (Pd) nanoparticles is fabricated via polystyrene nanosphere lithography and top‐down fabrication processes. The gas sensor shows dramatically improved H2 gas sensitivity compared with an Si thin film sensor without nanopatterns. Furthermore, a buffered oxide etchant treatment of the Si nanomesh structure...
In article number 1703691, Inkyu Park and co‐workers develop a high‐performance and low‐cost hydrogen gas sensor based on palladium decorated silicon nanomesh structure made through a polystyrene nanosphere self‐assembly method. The facile approach reported can also be very useful for high‐performance sensors for biological and chemical detection, with applications in mobile and wearable devices....
The development of artificial antigen presenting cells (aAPCs) to mimic the functions of APCs such as dendritic cells (DCs) to stimulate T cells and induce antitumor immune responses has attracted substantial interests in cancer immunotherapy. In this work, a unique red blood cell (RBC)‐based aAPC system is designed by engineering antigen peptide‐loaded major histocompatibility complex‐I and CD28...
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