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Background Recent studies have shown that the crosstalk between microRNA (miRNA) sponges plays an important role in human cancers. However, the co-regulation roles of miRNA sponges in protein-protein interactions (PPIs) are still unknown. Results In this study, we propose a multi-step method called miRSCoPPI to infer miRNA sponge co-regulation of PPIs. We focus on investigating breast cancer (BRCA)...
Background MicroRNA (miRNA) sponges with multiple tandem miRNA binding sequences can sequester miRNAs from their endogenous target mRNAs. Therefore, miRNA sponge acting as a decoy is extremely important for long-term loss-of-function studies both in vivo and in silico. Recently, a growing number of in silico methods have been used as an effective technique to generate hypotheses for in vivo methods...
In this paper, we propose a method to constrain and summarize optimal risk and preventive patterns in medical data using risk and preventive set with weight (RPSW) algorithm. The proposed method was tested by two benchmark medical data sets. The experiments show that the number of attribute-value items of the constraints was significant reduced and the results are understandable and intuitive.
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