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Abstract Endogenous pregnane steroids, such as allopregnanolone (3-hydroxy-5-pregnan-20-one; 3, 5-P) and pregnanolone (3-hydroxy-5-pregnan-20-one; 3,5-P), allosterically modulate GABAA receptor function and exhibit behavioral effects similar to benzodiazepines, though acting at a distinct recognition site. Inasmuch as some positive allosteric modulators of GABAA receptor function exhibit profound...
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