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Genetic association analysis of complex diseases has been limited by heterogeneity in their clinical manifestations and genetic etiology. Research has made it possible to differentiate homogeneous subtypes of the disease phenotype. Currently, the most sophisticated subtyping methods perform unsupervised cluster analysis using only clinical features of a disorder, resulting in subtypes for which genetic...
Identifying genetic variations that underlie human disease is very important to advance our understanding of the disease's pathophysiology and promote its personalized treatment. However, many disease phenotypes have complex clinical manifestations and a complicated etiology. Gene finding efforts for complex diseases have had limited success to date. Research results suggest that one way to enhance...
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