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CTLA‐4 is a crucial immune regulator that mediates both negative costimulation signals to T cells, and regulatory T (Treg)‐cell extrinsic control of effector responses. Here we present evidence supporting a novel mechanism for this extrinsic suppression, executed by the alternatively spliced soluble CTLA‐4 isoform (sCTLA‐4). Analyses of human T cells in vitro show that sCTLA‐4 secretion can be increased...
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