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Metabolomics generate a profile of small molecules from cellular/tissue metabolism, which could directly reflect the mechanisms of complex networks of biochemical reactions. Traditional metabolomics methods, such as OPLS-DA, PLS-DA are mainly used for binary class discrimination. Multiple groups are always involved in the biological system, especially for brain research. Multiple brain regions are...
The development of novel assays to detect collagen fragments is of utmost importance for diagnostic, prognostic and therapeutic decisions in various collagen-related diseases, and one essential question is to discover probe peptides that can specifically recognize target collagen sequences. Herein we have developed the fluorescence self-quenching assay as a convenient tool to screen the capability...
Soy sauce a well known seasoning all over the world, especially in Asia, is available in global market in a wide range of types based on its purpose and the processing methods. Its composition varies with respect to the fermentation processes and addition of additives, preservatives and flavor enhancers. A comprehensive 1H NMR based study regarding the metabonomic variations of soy sauce to differentiate...
In order to investigate the preclinical pharmacokinetics of cefuroxime lysine, a fast, sensitive and high throughput UPLC–ESI–MS/MS method has been developed and validated for the quantitative determination of cefuroxime in dog plasma. Cefuroxime and IS phenacetin were extracted from plasma samples by PPT or LLE procedure, and then separated on an ACQUITY UPLC™ BEH C 18 column with an isocratic...
Quantitative Structure-Retention Relationship (QSRR) studies were performed for predicting the retention times of 43 constituents of saffron aroma, which were analyzed by solid-phase micro-extraction gas chromatography–mass spectrometry (SPME-GC–MS). The chemical descriptors were calculated from the molecular structures of the constituents of saffron aroma alone, and the linear and non-linear QSRR...
As a novel type of learning machine method a support vector machine (SVM) was first used to develop a quantitative structure–property relationship (QSPR) model for the latest surface tension data of common diversity liquid compounds. Each compound was represented by structural descriptors, which were calculated from the molecular structure by the CODESSA program. The heuristic method (HM) was used...
CeO 2 /Chitosan (CHIT) composite matrix was firstly developed for the single-stranded DNA (ssDNA) probe immobilization and the fabrication of DNA biosensor related to the colorectal cancer gene. Such matrix combined the advantages of CeO 2 and chitosan, with good biocompatibility, nontoxicity and excellent electronic conductivity, showing the enhanced loading of ssDNA probe on the...
A microwave digestion method with HNO 3 alone was conducted at a temperature as high as 250°C for determination of 19 trace elements (Li, Be, V, Cr, Mn, Co, Ni, Cu, Zn, Ga, As, Se, Rb, Sr, Cd, Cs, Ba, Hg, and Pb) in coal jointly by inductively coupled plasma optical emission spectrometry (ICP-OES), inductively coupled plasma mass spectrometry (ICP-MS), and flow injection ICP-MS (FI-ICP-MS)...
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