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Adhesion of micro and nanoparticles onto cardiovascular walls is a critical process in applications such as targeted drug delivery, biomedical imaging, and cancer treatment. This paper intends to develop an understanding of the dynamic interaction between particle and vessel wall through computational modeling. The ligand-receptor binding dynamics is coupled with immersed finite element method to...
Summary form only given. Pathologists and cancer biologists rely on tissue and cellular analysis to study cancer expression, genetic profiles, and cellular morphology to understand the underlying basis for a disease and to grade the level of disease progression. Conventional analysis of tissue histology and sample cytology includes the steps of examination of the stained tissue or cell smear under...
Segmentation of cytological smears plays a critical role in the automated analysis of histological abnormalities by fine needle aspiration cytology. However, smears obtained from fine needle aspiration biopsy are often contaminated with blood. Segmentation of such an image is not a trivial task and the false positive rate could be high if the blood cells cannot be correctly separated from the rest...
This paper presents a multispectral microscopy system for quantitative cytology. The automated system aims to classify cytology samples of follicular lesions for the purpose of disease diagnosis. While conventional practices rely on the analysis of grey scale or RGB color images, presented system uses thirty one spectral bands for analysis. An intelligent system designed for image acquisition, image...
Over the last several years there has been an explosion of microarray technology in the biosciences, medical sciences, biotechnology, and pharmaceutical industry. The technology has centered on providing a platform for determining the gene expression profiles of hundreds to tens of thousands of genes (or transcript levels of RNA species) in tissue, tumors, cells, or biological fluids in a single experiment...
DNA copy number aberrations are common in cancer and other diseases. Newly developed array CGH technologies enable simultaneous measurement of DNA copy numbers for tens of thousands of sites within a genome. In array CGH experiments, DNA copy number of a test DNA sample relative to the DNA copy number of a reference DNA sample is measured. These relative measurements are mapped to their corresponding...
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