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The development of obliterative bronchiolitis (OB) is a major limitation for the long-term survival of allografts after lung transplantation. IL-17 play a key role in the pathogenesis of alloimmune-induced autoimmunity post lung transplantaion. Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation. While how IL-17 effect the development of OB remains elusive...
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