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We performed a study to look into the therapeutic application of a novel diagnostic and therapeutic agent, phase change nano droplet (PCND), in combination with 1-MHz ultrasound. It was found using gel phantoms that PCND works as a cavitation accelerator for a 1-MHz ultrasound only when an ultrasound which changes the phase of PCND from liquid to gas (phase change ultrasound) is exposed in advance...
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