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The hepatoprotective efficacy of irradiated hyaluronic acid (HA) on acetaminophen (APAP) induced acute hepatotoxicity was investigated. BALB/c mice (4–6 weeks of age) were pretreated with unirradiated HA (UIHA), 5 and 50kGy gamma irradiated HA (GIHA) for 14 days and were dosed APAP (500mg/kgb.wt). After 9h of APAP dosing animals were euthanized. The degree of acute hepatotoxicity was measured by aspartate...
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