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The PDZ-binding kinase/T-LAK cell–originated protein kinase (PBK/TOPK) is highly expressed in many types of tumors. However, its role in lung adenocarcinoma remains elusive. The aims of this study were to investigate the correlation between PBK/TOPK and mutant p53 in lung adenocarcinoma and to evaluate the effect of PBK/TOPK on cell proliferation and viability. Expression of PBK/TOPK and mutant p53...
AimsThe aim of this study was to evaluate the prevalence of PBK/TOPK (PDZ‐binding kinase/T‐LAK cell‐originated protein kinase) expression, and explore the prognostic significance of PBK/TOPK expression alone and in combination with Ki67 and p53 expression in non‐small‐cell lung cancer (NSCLC).
Methods and resultsWe detected PBK/TOPK expression in 30 samples of normal lung tissue, 32 lymph node metastases...
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