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Xanthii Fructus (XF) has been used for treatment of allergic rhinitis (AR), but its pharmacological mechanism of action remains unclear. We aimed to explore the potential mechanism of XF in treatment of AR by using a network pharmacology approach combined with in vivo verification experiments in this study. We identified 945 AR‐related pathogenic genes, 11 active components in XF and 178 targets of...
Background
MicroRNA (miR)‐146a, as an important immune regulatory factor with an anti‐inflammatory effect, plays a crucial role in regulatory T‐cell (Tregs) differentiation and function in allergic rhinitis (AR). The present study aimed to investigate the regulatory mechanism employed by miR‐146a to control Treg differentiation and function in AR.
Methods
Expression of miR‐146a and STAT5b in peripheral...
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