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Currently there is no effective therapy for most patients with fulminant or end stage liver disease.Pig liver micro-organs (LMOs), which preserve liver micro-architecture and ensure a maximal 150–200μm distance from a source of nutrients and gases have been prepared and a method to cryo-preserve them has been developed. A new scaled-up extra-corporeal liver device termed aLIVE-H in which LMOs are...
Background/Aims: Currently there is no effective non-surgical therapy for most patients with fulminant or end stage chronic liver disease.Methods: We have prepared rat liver micro-organs (LMOs), which preserve the liver micro-architecture and ensure that no cell is more than 150 μm away from a source of nutrients and gases. The function of LMOs has been evaluated in vitro and in a new extra-corporeal...
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