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Rare variants of phospholipase D3 (PLD3) have been identified as Alzheimer’s disease (AD) susceptibility loci, whereas little is known about the potential role of common variants in the progression of AD. To examine the impact of genetic variations in PLD3 on neuroimaging phenotypes in a large non-demented population. A total of 261 normal cognition (NC) and 456 mild cognitive impairment (MCI) individuals...
The apolipoprotein E ε4 (APOE ε4) allele is the most important genetic risk factor for Alzheimer’s disease (AD); however, the underlying mechanisms responsible for it remain controversial. We used the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database to examine the influence of APOE ε4 dose on clinical and neuroimaging biomarkers across the AD spectrum (from cognitive normal to AD patients...
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