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As a ligand for peroxisome proliferators-activated receptor γ (PPARγ), troglitazone inhibits cell growth by mechanisms besides activating PPARγ. In this study, we found that troglitazone interfered with the interactions between estrogen-related receptor α and γ (ERRα and ERRγ) and their coactivator PPARγ coactivator-1α (PGC-1α) functioning as an inverse agonist. Additionally, troglitazone suppressed...
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