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We have investigated the effects of imperatoxin A (IpTxa) on local calcium release events in permeabilized frog skeletal muscle fibers, using laser scanning confocal microscopy in linescan mode. IpTxa induced the appearance of Ca2+ release events from the sarcoplasmic reticulum that are ∼2s and have a smaller amplitude (31±2%) than the “Ca2+ sparks” normally seen in the absence of toxin. The frequency...
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