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COVID‐19 Therapy
In their work reported in article number 2103471, Long Zhang, Fangfang Zhou, and co‐workers fuse the S‐palmitoylation‐dependent plasma membrane (PM) targeting sequence with angiotensin converting enzyme 2 (ACE2) and engineer extracellular vesicles (EVs) on their surface enriched with palmitoylated ACE2 (PM‐ACE2‐EVs). The PM‐ACE2‐EVs can bind to the SARS‐CoV‐2 S‐RBD with high affinity...
Angiotensin converting enzyme 2 (ACE2) is a key receptor present on cell surfaces that directly interacts with the viral spike (S) protein of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). It is proposed that inhibiting this interaction can be promising in treating COVID‐19. Here, the presence of ACE2 in extracellular vesicles (EVs) is reported and the EV‐ACE2 levels are determined...
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