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An elasticity microcytometer capable of multiparametric biomechanical and biochemical phenotypic profiling of single cancer cells is developed to interpret cell deformation along antibody‐coated confining microchannels as quantitative cell characteristics including cell size, cell deformability/stiffness, and expression levels of surface receptors simultaneously for the same single live cancer cells...
Deep phenotyping of single cancer cells is of critical importance in the era of precision medicine to advance understanding of relationships between gene mutation and cell phenotype and to elucidate the biological nature of tumor heterogeneity. Existing microfluidic single‐cell phenotyping tools, however, are limited to phenotypic measurements of 1–2 selected morphological and physiological features...
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