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Identifying novel neuroprotectants that can halt or even reverse the effects of stroke is of interest to both clinicians and scientists. Neuregulin 1 (NRG1) is an effective neuroprotectant, but its molecular mechanisms are largely unclear. In this study, NRG1 rescued cortical neurons from oxygen-glucose deprivation (OGD) model, but the effect was blocked by neutralizing NRG1 and ErbB4 inhibition....
Adrenoceptors have been suggested to mediate neuronal development. This study revealed the expression of α2A adrenoceptors in the cortical plate of fetal mouse cerebral wall. The effects of α2A adrenoceptor on dendrite growth were investigated in primary neuronal cultures. Application of α2 adrenoceptor agonists, BHT 933 or UK 14304 for 24 or 72 h resulted in a 1.5-2-fold increase in dendrite lengths...
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