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Integrins play an important role in tumor metastasis induced by vascular endothelial growth factor (VEGF). However, in the case of gastric cancer, the precise role of VEGF in regulating integrin αvβ6 is unclear. In this study, we found that most of the αvβ6 integrin-positive gastric cancer tissues were also VEGF-positive. Furthermore, when gastric carcinoma cells were exposed to VEGF, expression of...
Considerable researches have been done about integrin ανβ6 and carcinomas, but little information has been shown about the relationship between integrin ανβ6 and apoptosis. In this study, we investigated the apoptosis and its related signal pathways to integrin αvβ6 in colon cancer cells. After we blocked the function of integrin αvβ6 in HT29 cells used the monoclonal antibody, the apoptotic cells...
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