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Long-term metformin treatment reduces the risk of stroke. However, the effective administration pattern and indications of metformin on acute cerebral ischemia are unclear. To investigate the neuroprotective treatment duration and dosage of metformin on focal ischemia mice and the association of neuroprotection with 5′-adenosine monophosphate-activated protein kinase (AMPK) regulations, male C57BL...
AimLactates accumulate in ischemic brains. G protein‐coupled receptor 81 (GPR81) is an endogenous receptor for lactate. We aimed to explore whether lactate is involved in ischemic injury via activating GPR81.
MethodsN2A cells were transfected with GFP‐GPR81 plasmids 24 h previously, and then treated with GPR81 antagonist 3‐hydroxy‐butyrate (3‐OBA) alone or cotreated with agonists lactate or 3, 5‐dihydroxybenzoic...
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