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Febrile neutropenia (FN) is a common and serious complication among cancer patients undergoing myelosuppressive chemotherapy. FN should be treated as a medical emergency because it can lead to life-threatening complications if appropriate treatment is not initiated immediately. This study provides a critical review on the current management of FN and identifies possible directions to optimize FN management.
A concept of hierarchical stiffened shell is proposed in this study, aiming at reducing the imperfection sensitivity without adding additional weight. Hierarchical stiffened shell is composed of major stiffeners and minor stiffeners, and the minor stiffeners are generally distributed between adjacent major stiffeners. For various types of geometric imperfections, e.g., eigenmode-shape imperfections,...
Mechanical engineers always expect to design a structure which could work properly in its whole lifetime. But there exist many random factors, such as dimension, material property and applied forces. Hence structures based on determinate design could fail with high probability. Reliability-based Topology Optimization (RBTO) is a computer-automated design method which combines reliability analysis...
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