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Retinoic acid receptor‐related orphan nuclear receptor γ (RORγ) orchestrates a pro‐inflammatory gene expression programme in multiple lymphocyte lineages including T helper type 17 (Th17) cells, γδ T cells, innate lymphoid cells and lymphoid tissue inducer cells. There is compelling evidence that RORγ‐expressing cells are relevant targets for therapeutic intervention in the treatment of autoimmune...
Multiple sclerosis (MS) is a chronic inflammatory disease that causes demyelination of neurons in the central nervous system. Traditional therapies for MS have involved anti‐inflammatory and immunosuppressive drugs with significant side effects that often only provide short‐term relief. A more desirable outcome of immunotherapy would be to protect against disease before its clinical manifestation...
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