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In article number 1900140, Lei Zhang and co‐workers report an effective immune‐evasive hydrogel that can well accommodate islets and maintain their glucose‐responsive and insulin‐producing functions. This novel strategy can achieve dynamic, long‐term, stable regulation of blood glucose levels in diabetic mice and endow them with pancreas functionality after intraperitoneal implantation.
Transplantation of encapsulated islets is a promising treatment for patients with type 1 diabetes mellitus. However, its long‐term clinical therapeutic efficacy is still hindered by serious immune rejection from the host immunological responses to the implanted materials, known as foreign body reaction (FBR). In this work, an anti‐biofouling balanced charged hydrogel is reported that can serve as...
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