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Background Chronic intermittent hypoxia is the primary pathophsiological feature of obstructive sleep apnea/hypopnea syndrome. The characteristics of CIH can be imitated by animal experiment models thus to study CIH related systemic organ injuries, including respiratory systems. Methods Sixteen male SD rats were randomly divided into two groups: CIH group (n = 8) and control group (n = 8). The CIH...
Chronic intermittent hypoxia (CIH) is the main pathophysiological feature of obstructive sleep apnea (OSA). It destroys the normal sleep rhythm and affects many basic physiological processes, leading to repeated arousal from sleep. Orexin, a very potent arousal neuromodulator found in the brain, has been shown to play a significant role in the promotion and maintenance of arousal. These findings may...
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