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This paper presents utilization of pulsed terahertz imaging to detect and assess the margins of excised human breast tumors. The freshly excised bulk tissue and the block of the same tissue fixed in formalin and embedded in paraffin (FFPE) are scanned using the reflection imaging module. The results show that while the THz images of block tissue demonstrate strong contrast between cancerous and fibroglandular...
This work utilizes xenograft murine breast cancer tumors to develop terahertz imaging methodology for freshly excised breast cancer tissue. Tumors are grown via cell injection into mice on a high-fat diet and excised for subsequent terahertz imaging. Following imaging of both freshly excised tumor bulk and interior cross-sections, the tumors are then subjected to histopathology processing for correlation...
This work investigates the use of terahertz imaging for differentiating between cancer and healthy tissue regions in freshly excised breast cancer tumors. Bulk tissue specimens are obtained fresh in a nutrient medium from a biobank and scanned on a pulsed terahertz system in the reflection mode to produce the reflection image. Tissues are then sent for histopathology processing, and the subsequent...
This paper presents numerical simulation of terahertz imaging of heterogeneous material that mimics excised breast cancer tissue sections. The finite-element package ANSYS High Frequency Structural Simulator is used in this work. A model based on a pathology section is developed to obtain the image at 1 THz. The simulated image is compared with the experimental image at the same frequency. The results...
This paper presents experimental terahertz spectroscopy measurements of normal and breast cancer tissue in the range 0.1 to 4 THz. Both tissue types are prepared on microscope glass and polystyrene slides. The preliminary results of a particular tumor tissue using terahertz spectroscopy align with the pathology diagnosis of poorly differentiated tumor. The results demonstrate the potential of terahertz...
This work shows the basis for the use of the Linear Sampling Method (LSM) for imaging breast cancer tumor margins. The LSM has shown capability of low computational cost and qualitative shape and tomography image reconstruction in the microwave frequency range. Terahertz image reconstruction results of excised breast cancer tumor margins will be presented in the conference. The LSM algorithm will...
This research involves the use of a terahertz imaging and spectroscopy system to conduct spectrometry on excised breast tissue. Breast cancer lumpectomy is the process of removing a malignant tumor from breast tissue. During the procedure, a portion of the surrounding tissue, known as the margins, is also removed. The margin tissue undergoes examination by a pathologist in order to determine whether...
The robust shape reconstruction level set algorithm has proven its capability for reconstructing the exact shape and location of unknown 2D and 3D targets. However, the computational time of the level set algorithm can be extensive especially for complex multi-scale targets. In order to eliminate this burden, the qualitative Linear Sampling Method (LSM) is investigated to generate the initial guess...
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