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Pulmonary nodule is a common lung disease, which can be prone to misdiagnosis and missed diagnosis. With the extensive application of CT technology, doctor's diagnostic efficiency has been greatly improved. However, the amount of CT image data is relatively large. Radiologists have to take a lot of time to read these images, and easy to overlook some minor lesions. Computer aided detection technology...
Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs with length more than 200 nucleotides. LncRNAs played important roles in many biological processes such as cell development, proliferation, invasion and migration. Deregulation of LncRNAs was found in multiple tumors where they can act as a tumor suppressor gene or oncogene. LncRNA ANRIL was identified as an oncogene involved in...
TARBP2 is a RNA-binding protein (RBP) involved in miRNA processing and maturation. TARBP2 plays significant roles in many biological and pathological conditions, including viral expression of HIV-1, microsatellite instability, cancer stem cell properties, and tumor progression. Overexpression of TARBP2 was observed in many cancers such as prostate cancer, cutaneous malignant melanoma, and adrenocortical...
People exposure to ambient polycyclic aromatic hydrocarbons (PAHs) in Tianjin area was estimated based on field data of media concentrations and other data from the literature. A multi-pathway human exposure model by USEPA was employed to calculate the populations' Chronic Daily Intake (CDI) of PAHs. The results showed that the CDI of child, adolescent and adult were 2.92, 2.33 and 1.90 mg/(kg×d),...
This study proposes a set of novel feature vectors for accurate differentiation of 3 typical types of liver space-occupying lesions in ultrasound images. Experiments were performed on 280 cases of liver images, including 112 cases of normal liver images, 90 cases of liver cancer images, 38 cases of liver hemangioma images and 40 cases of liver cyst images. First, we defined two types of region of...
The sensitivity of hepatoma cells to total aqueous extract(TAE) from Artemisia argyi was investigated. HepG2 cells were treated with the extract at the concentrations of 17.5 mg(Artemisia argyi)/ml, 35 mg(Artemisia argyi)/ml, and 70mg(Artemisia argyi)/ml. Inverted microscope observation found that the total aqueous extract induced cell shrinkage after 12h, and ultimately cell death after persistent...
Objectives: To compare anti-tumor activities of different extracts from the medicinal plants Pinellia ternata and its allied species.Methods: MTT cell proliferation assay was used to evaluate the cytotoxicity of the extracts on Bel-7402, HT-29, Hela cells. FCM assay and DNA fragmentation analysis were used to detect cell apoptosis. Immunohistochemical SABC method was performed for detection of the...
The anti-tumor activities of six medical plants (Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Duchesneae Indicae, Herba Solani Lyrati, Rhizoma Smilacis Glabrae, Rhizoma Paridis Chinensis), commonly used as antitumor drugs, have been submitted to tests of MTT, Flow cytometry (FCM), DNA laddering analysis and caspase-3 expression using Bel-7402, HT-29 and HeLa cell lines. Total alkaloids...
Fourier descriptor is an important method used in shape analysis and recognition. A novel method for designing the classifier of multi-dimensional data was proposed, which used radar chart of multi-statistics to show multidimensional data and applied Fourier descriptors to recognize the radar chart. Different multi-dimensional data formed different radar chart and distinguished different category...
Prostate specific antigen (PSA) is a major biomarker used clinically in the detection of prostate cancer. Current commercial immunoassays for detection of this biomarker rely on spectroscopic absorbance and electro-chemiluminescence which are able to detect as low as 0.03 ng/mL of PSA within 100muL of serum. In this paper, a novel amplified electrochemical technique for detection of prostate specific...
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