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Objective: The reduction in insulin secretory capacity and β‐cell mass has been attributed, at least partially, to lipotoxicity, which may contribute to the development of type 2 diabetes. Chronic free fatty acids (FFA) exposure impairs pancreatic β‐cell function and induces β‐cell apoptosis. This study is to elucidate the underlying molecular mechanisms.
Research design and methods: We exposed INS‐1E...
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