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Objective To study the combined antitumor effect and possible mechanisms of ursolic acid with 5-fluorouracil (5-FU) on human esophageal carcinoma cell Eca-109 in vitro. Methods Eca-109 cells were treated with ursolic acid (10–50 μmol/L) and/or 5-fluorouracil (48.0–768.8 μmol/L) for 48 h in vitro. And then cell proliferation was determined by MTT assay. Cell cycle and apoptosis rate were analyzed...
γ-Tocotrienol is a major component of the tocotrienol-rich fraction of palm oil, but there is limited evidence that it has antitumor activity. In particular, the effects of γ-tocotrienol on human colon carcinoma cells have not been reported. To investigate the chemopreventive effects of γ-tocotrienol on colon cancer, we examined its capacity to inhibit proliferation and induce apoptosis in HT-29 cells...
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