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•Ang II induced muscle wasting is mediated by TNF-α, which in turn up regulates Ch25h•Knockout of TNFR1 inhibits the production of 25-OHC and blocks ang II induced muscle loss in mice•25-OHC injection induces muscle wasting in mice by activating GSK3β•A GSK3β inhibitor blocks ang II induced muscle atrophy, which paves the way for targeted therapy to treat muscle wastingCardiac cachexia (CC), a condition...
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