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Here, we show the involvement of signaling pathways to induce the gene expression of bone morphogenetic protein (BMP) in the osteogenic activity of physcion‐8‐O‐β‐D‐glucopyranoside (physcion‐Glu); it stimulated osteoblast differentiation in mouse osteoblast MC3T3‐E1 subclone 4 cells and induced BMP‐2 gene expression and activation of Akt and ERK/MAP kinases. Physcion‐Glu‐induced BMP‐2 expression and...
In this study, we demonstrate a stimulatory effect of tanshinone IIA isolated from the root of Salvia miltiorrhiza on the commitment of bi-potential mesenchymal precursor C2C12 cells into osteoblasts in the presence of bone morphogenetic protein (BMP)-2. At low concentrations, tanshinone IIA enhanced BMP-2-stimulated induction of alkaline phosphatase (ALP), an early phase biomarker of osteoblast differentiation,...
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