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This study was aiming to investigate the fabrication and characterization of the porous chitosan/gelatin scaffold cross-linked with genipin (GP) which is widely used as a natural and non-toxic cross-linking agent. The chitosan/gelatin scaffold was prepared and cross-linked with 1% or 2%(w/w) genipin for 24 hours at 37degC, then pre-freezing for 48h at -20degC and -80degC before freeze drying. As a...
Biodegradable polymers have been widely used as scaffolding materials to regenerate new tissues. To mimic natural extracellular matrix architecture, a novel highly porous structure, which is a three-dimensional interconnected fibrous network with a fiber diameter ranging from 100 to 500 nm, has been created from poly (L-lactic acid) in this work. These fibrous matrices were prepared from the polymer...
In the present study, poly (D, L-lactic acid) (PDLLA) modified genipin-cross-linked chitosan/gelatin scaffolds loaded icariin were prepared. The scaffolds with genipin cross-linking were fabricated with lyophilization, and then were immersed into the 2.5%, 5.0%, and 7.5% PDLLA-dichloromethane solutions. Thus the PDLLA modified genipin-cross-linked scaffolds were obtained after evaporating the solvent...
The objective of this study was to investigate the efficiency of poly (L-lactic acid) (PLLA) surface modification with chitosan and gelatin. The properties of original PLLA films and modified PLLA films were investigated by water contact angle measurement and electron spectroscopy for chemical analysis (ESCA). The attachment and proliferation of bovine articular chondrocytes seeded on modified PLLA...
In this study, L929 cell adhesion, proliferation and apoptosis were investigated on chitosan (CS) and chitosan-gelatin (CS-Gel) membranes having different degrees of deacetylation (DD). The mitochondrial activity [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay results demonstrated that the DD played a key role in the L929 cell adhesion. Indeed, the higher the DD of a CS membrane,...
The objective of this study was to investigate the efficiency of two treatments for poly(l-lactic acid) (PLLA) surface modification with chitosan, via entrapment and coupling by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide. The properties of original PLLA films, chitosan-entrapped and coupled PLLA films were investigated by water contact angle measurement and electron...
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