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Topographical features are known to physically affect cell behavior and are expected to have great potential for non-invasive control of such behavior. To provide a design concept of a microstructured surface for elaborate non-invasive control of cell migration, we systematically analyzed the effect of microgrooves on cell migration. We fabricated silicon microstructured surfaces covered with SiO...
Cell migration control techniques have been proposed for cells with relatively low migratory activity, based on static analyses performed with cells that attain a temporally homogenous state after being exposed to a cell guiding stimulus. To elucidate new functions of substrate topography, we investigated the transient change in the behavior of highly migratory cells coming from a flat surface to...
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