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Store-operated Ca 2+ entry is the major route of replenishment of intracellular Ca 2+ in animal cells in response to the depletion of Ca 2+ stores in the endoplasmic reticulum. It is primarily mediated by the Ca 2+ -selective release-activated Ca 2+ (CRAC) channel, which consists of the pore-forming subunits ORAI1–3 and the Ca 2+ sensors, STIM1 and STIM2...
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