Search results for: M. Hoff

Items from 1 to 20 out of 147 results

article

Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer

Kristina T. Carm, Bjarne Johannessen, Mari Bogaard, Anne Cathrine Bakken, more

International Journal of Cancer > 152 > 5 > 945 - 951

Primary prostate cancer shows a striking intraorgan molecular heterogeneity, with multiple spatially separated malignant foci in the majority of patients. Metastatic prostate cancer, however, typically reveals more homogenous molecular profiles, suggesting a monoclonal origin of the metastatic lesions. Longitudinal mutational spectra, comparing multiple primary lesions with metastases from the same...

article

Loss and rescue of osteocalcin and osteopontin modulate osteogenic and angiogenic features of mesenchymal stem/stromal cells

Marta S. Carvalho, João C. Silva, Christopher M. Hoff, Joaquim M. S. Cabral, more

Journal of Cellular Physiology > 235 > 10 > 7496 - 7515

Noncollagenous proteins in the bone extracellular matrix, such as osteocalcin (OC) and osteopontin (OPN), inherent to evolution of bone as a skeletal tissue, are known to regulate bone formation and mineralization. However, the fundamental basis of this regulatory role remains unknown. Here, for the first time, we use mouse mesenchymal stem/stromal cells (MSC) lacking both OC and OPN to investigate...

article

Exploring the Relationship between FEV₁ Loss and Recovery and Aminoglycoside Pharmacokinetics in Adult Patients with Cystic Fibrosis: Implications for Clinical Dosing Strategies

Brian M. Hoff, Marc H. Scheetz, Manu Jain, Joanne F. Cullina, more

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy > 40 > 6 > 584 - 591

Objective Systemic aminoglycosides remain a cornerstone of treatment for cystic fibrosis (CF) pulmonary exacerbations (PEx); however, the impact of aminoglycoside pharmacokinetics (PK) on outcomes is not well defined in adult CF patients. Our objective was to assess the impact of increasing PK exposures on the clinical outcomes of PEx treatment in adult CF patients receiving high‐dose and standard‐dose...

article

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

A. Bhangu, RIFT Study Group on behalf of the West Midlands Research Collaborative, D Nepogodiev, JH Matthews, more

British Journal of Surgery > 107 > 1 > 73 - 86

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all...

article

We moeten eens om tafel: samen aan het werk met gezinnen met meervoudige problemen

L. Hal, R. Gilsing, M. Hoff

JGZ Tijdschrift voor jeugdgezondheidszorg > 2019 > 51 > 6 > 152-156

Samenvatting Inleiding: De werkwijze 1Gezin1Plan (1G1P) is gericht op een gezamenlijk plan in de hulp en ondersteuning aan gezinnen met meervoudige problematiek, waarbij meerdere personen en instanties betrokken zijn. In dit artikel gaan we in op de samenwerking tussen verschillende partijen binnen 1G1P, in het bijzonder op de rondetafeloverleggen met al die partijen.Methode: Dit artikel is gebaseerd...

article

Pharmacokinetic and exposure–response analysis of pertuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer

Whitney P. Kirschbrown, Bei Wang, Ihsan Nijem, Atsushi Ohtsu, more

Cancer Chemotherapy and Pharmacology > 2019 > 84 > 3 > 539-550

Purpose To characterize the pharmacokinetics (PK) of pertuzumab and trastuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer in the randomized, double-blind, phase III JACOB study (NCT01774786), and to evaluate the appropriateness of the pertuzumab regimen in these patients. Methods Patients received 840 mg intravenous pertuzumab or placebo plus trastuzumab...

article

Hospital based care at home; study protocol for a mixed epidemiological and randomized controlled trial

Ingebjørg Irgens, Jana M. Hoff, Hilde Sørli, Hanne Haugland, more

Trials > 2019 > 20 > 1 > 1-12

Background Individuals with spinal cord injuries (SCI) are prone to pressure ulcers (PUs) because of the loss of sensorimotor function involved as well as increased skin moisture. Treatment of PU after SCI is complicated, involving different specialties and with need for long-lasting follow-up. This study should identify risk factors for PU after SCI, and find an effective and less time-consuming...

article

Return to work after breast cancer diagnosis: An observational prospective study in Brazil

Luciana C. G. Landeiro, Debora M. Gagliato, Angelo B. Fêde, Natalia M. Fraile, more

Cancer > 124 > 24 > 4700 - 4710

Background In North America and Europe, return‐to‐work (RTW) rates vary among breast cancer (BC) survivors, from 24% to 66% and from 53% to 82% at 6 and 36 months after diagnosis, respectively. To date, there is a lack of data on RTW rates after BC diagnosis in Latin America. Therefore, the primary objectives of this study were to define RTW rates at 12 and 24 months after BC diagnosis and to identify...

article

Exotic Spinorial Structure and Black Holes in General Relativity

D. Beghetto, R. T. Cavalcanti, J. M. Hoff Silva

Advances in Applied Clifford Algebras > 2018 > 28 > 5 > 1-15

We explore different (and complementary) views of spinors and their exotic counterparts, linking the very existence of the later to the presence of black holes. Moreover, we investigate the effects of the exotic term in the Hawking radiation emission rate, as well as its extremes, for asymptotically flat black holes solutions of general relativity. We show that, under certain circumstances, the emission...

article

Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing

Srinivas R. Viswanathan, Gavin Ha, Andreas M. Hoff, Jeremiah A. Wala, more

Cell > 2018 > 174 > 2 > 433-447.e19

Nearly all prostate cancer deaths are from metastatic castration-resistant prostate cancer (mCRPC), but there have been few whole-genome sequencing (WGS) studies of this disease state. We performed linked-read WGS on 23 mCRPC biopsy specimens and analyzed cell-free DNA sequencing data from 86 patients with mCRPC. In addition to frequent rearrangements affecting known prostate cancer genes, we observed...

article

Serum levels of VEGF and MCSF in HER2+ / HER2- breast cancer patients with metronomic neoadjuvant chemotherapy

Roberto J. Arai, Vanessa Petry, Paulo M. Hoff, Max S. Mano

Biomarker Research > 2018 > 6 > 1 > 1-6

Metronomic therapy has been gaining importance in the neoadjuvant setting of breast cancer treatment. Its clinical benefits may involve antiangiogenic machinery. Cancer cells induce angiogenesis to support tumor growth by secreting factors, such as vascular endothelial growth factor (VEGF). In breast cancer, Trastuzumab (TZM) based treatment is of key importance and is believed to reduce diameter...

article

Braneworld gravity within non-conservative gravitational theory

J. C. Fabris, Thiago R. P. Caramês, J. M. Hoff Silva

The European Physical Journal C > 2018 > 78 > 5 > 1-6

We investigate the braneworld gravity starting from the non-conservative gravitational field equations in a five-dimensional bulk. The approach is based on the Gauss–Codazzi formalism along with the study of the braneworld consistency conditions. The effective gravitational equations on the brane are obtained and the constraint leading to a brane energy-momentum conservation is analyzed.

article

Anti-osteoporosis drug use: too little, too much, or just right? The HUNT study, Norway

M. Hoff, S. Skurtveit, H.E. Meyer, A. Langhammer, more

Osteoporosis International > 2018 > 29 > 8 > 1875-1885

Summary Use of anti-osteoporotic drugs (AODs) was examined in a Norwegian population 50–85 years. Among them with Fracture Risk Assessment Tool (FRAX) score for major osteoporotic fracture ≥ 20, 25% of the women and 17% of the men received AODs. The strongest predictors for AODs were high age in women and use of glucocorticoids among men. Introduction To examine the use of anti-osteoporotic drugs...

article

Opening the Pandora’s box of quantum spinor fields

L. Bonora, J. M. Hoff Da Silva, R. Da Rocha

The European Physical Journal C > 2018 > 78 > 2 > 1-15

Lounesto’s classification of spinors is a comprehensive and exhaustive algorithm that, based on the bilinears covariants, discloses the possibility of a large variety of spinors, comprising regular and singular spinors and their unexpected applications in physics and including the cases of Dirac, Weyl, and Majorana as very particular spinor fields. In this paper we pose the problem of an analogous...

article

Visual field defect after ischemic stroke—impact on mortality

K. M. Sand, H. Næss, L. Thomassen, J. M. Hoff

Acta Neurologica Scandinavica > 137 > 3 > 293 - 298

Objectives We aimed to investigate the impact of visual field defects (VFD) on mortality in ischemic stroke patients. Materials and methods All patients with acute infarction and a clinically detected VFD from February 2006 to December 2013 in the NORSTROKE Registry (n = 506) were included and compared with ischemic stroke patients with normal visual fields (n = 2041). A record of patients who...

article

CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension

Ricardo Celestino, Torfinn Nome, Ana Pestana, Andreas M. Hoff, more

BMC Cancer > 2018 > 18 > 1 > 1-16

Background The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. Methods We used high-throughput paired-end RNA sequencing technology to study four cases of FTC with different...

article

A nearly cylindrically symmetric source in Brans–Dicke gravity as the generator of the rotational curves of the galaxies

S. Mittmann Santos, J. M. Hoff Silva, M. E. X. Guimarães, J. L. Neto

The European Physical Journal C > 2017 > 77 > 12 > 1-13

Observation shows that the velocities of stars grow by approximately 2–3 orders of magnitude when the distances from the centers of the galaxies are in the range of 0.5–82.3 kpc, before they begin to tend to a constant value. Up to now, the reason for this behavior is still a matter for debate. In this work, we propose a model which adequately describes this unusual behavior using a (nearly) cylindrical...

article

f(R)-Einstein-Palatini formalism and smooth branes

P. Michel L. T. da Silva, J. M. Hoff da Silva

The European Physical Journal Plus > 2017 > 132 > 10 > 1-7

. In this work, we present the $ f(R)$ f ( R ) -Einstein-Palatini formalism in arbitrary dimensions and the study of consistency applied to brane models, the so-called braneworld sum rules. We show that a scenario of thick branes in five dimensions with compact extra dimension in the framework of the $ f(R)$ f ( R ) -Einstein-Palatini theory is possible by the accomplishment...

article

Radiomic Features Extracted from Magnetic Resonance Imaging (MRI) Are Associated with Clinical Outcomes in Low-Grade Glioma

S.E. Day, M.B. Spraker, L. Wootton, D.S. Hippe, more

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E69

article

Combination of Irinotecan, Oxaliplatin and 5-Fluorouracil as a Rechallenge Regimen for Heavily Pretreated Metastatic Colorectal Cancer Patients

Gustavo Dos Santos Fernandes, Maria Ignez Braghiroli, Michelle Artioli, Ana Carolina Carvalho Rocha Paterlini, more

Journal of Gastrointestinal Cancer > 2018 > 49 > 4 > 470-475

Purpose Our objective was to evaluate the benefit of re-exposing patients with refractory metastatic colorectal cancer (mCRC) to a combination of oxaliplatin, irinotecan and 5-fluorouracil treatment. Methods We retrospectively analysed patients with mCRC who received a combination of oxaliplatin, irinotecan and fluorouracil as a rechallenge regimen after progressing on the same drugs. Both FOLFOXIRI...

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INFONA - science communication portal

Search results for: M. Hoff

Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer

Loss and rescue of osteocalcin and osteopontin modulate osteogenic and angiogenic features of mesenchymal stem/stromal cells

Exploring the Relationship between FEV₁ Loss and Recovery and Aminoglycoside Pharmacokinetics in Adult Patients with Cystic Fibrosis: Implications for Clinical Dosing Strategies

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

We moeten eens om tafel: samen aan het werk met gezinnen met meervoudige problemen

Pharmacokinetic and exposure–response analysis of pertuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer

Hospital based care at home; study protocol for a mixed epidemiological and randomized controlled trial

Return to work after breast cancer diagnosis: An observational prospective study in Brazil

Exotic Spinorial Structure and Black Holes in General Relativity

Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing

Serum levels of VEGF and MCSF in HER2+ / HER2- breast cancer patients with metronomic neoadjuvant chemotherapy

Braneworld gravity within non-conservative gravitational theory

Anti-osteoporosis drug use: too little, too much, or just right? The HUNT study, Norway

Opening the Pandora’s box of quantum spinor fields

Visual field defect after ischemic stroke—impact on mortality

CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension

A nearly cylindrically symmetric source in Brans–Dicke gravity as the generator of the rotational curves of the galaxies

f(R)-Einstein-Palatini formalism and smooth branes

Radiomic Features Extracted from Magnetic Resonance Imaging (MRI) Are Associated with Clinical Outcomes in Low-Grade Glioma

Combination of Irinotecan, Oxaliplatin and 5-Fluorouracil as a Rechallenge Regimen for Heavily Pretreated Metastatic Colorectal Cancer Patients

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