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A group of podophyllotoxin (PPT) derivatives (7a–j) were synthesized by conjugating aryloxyacetanilide moieties to the 4′-hydroxyl of 4′-demethyl-4-deoxypodophyllotoxin (DDPT), and their anticancer activity was evaluated. It was found that the most potent compound 7d inhibited the proliferation of three cancer cell lines with sub to low micromolar IC50 values. Furthermore, it was demonstrated that...
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