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Background
Central nervous system (CNS) aspergillosis is an uncommon but fatal disease, the diagnosis of which is still difficult.
Objectives
We aim to explore the diagnositic performance of noncultural methods for CNS aspergillosis.
Methods
In this retrospective study, all pathologically confirmed rhinosinusitis patients in whom cerebrospinal fluid (CSF) galactomannan (GM) test and metagenomic...
Background
Cryptococcal meningitis (CM) is increasingly recognised in human immunodeficiency virus (HIV)‐uninfected patients with high mortality. The efficacy and safety profiles of induction therapy with high‐dose fluconazole plus flucytosine remain unclear.
Methods
HIV‐uninfected CM patients who received high‐dose fluconazole (800 mg/d) for initial therapy in Huashan Hospital were included in...
Background
Cryptococcal meningitis (CM)‐associated immune reconstitution inflammatory syndrome (IRIS) is associated with high mortality, the epidemiology and pathophysiology of which is poorly understood, especially in non‐HIV populations.
Objectives
We aim to explore the incidence, clinical risk factors, immunological profiles and potential influence of leukotriene A4 hydroxylase (LTA4H) on non‐HIV...
Background
Causes of voriconazole‐related visual adverse events (VVAE) remained controversial.
Objectives
We aimed to explore the relationship between voriconazole serum concentrations and VVAE as well as the potential influence of transient receptor potential melastatin 1 (TRPM1) on VVAE.
Patients/methods
This prospective observational cohort study was done in two stages. Patients who received...
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