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Deoxyribozymes are synthetic enzymes made of DNA that can catalyze the cleavage or formation of phosphodiester bonds and are useful tools for RNA biochemistry. Herein, we report new RNA‐cleaving deoxyribozymes to interrogate the methylation status of target RNAs, thereby providing an alternative method for the biochemical validation of RNA methylation sites containing N6‐methyladenosine, which is...
Die Adenosin‐Methylierung in RNA wird in der Zuschrift auf S. 15337 von C. Höbartner und Mitarbeitern mithilfe von Deoxyribozymen untersucht. Sie stellen neue RNA‐spaltende DNA‐Enzyme vor, die spezifische Adenosine in RNA auf das Vorliegen einer Methylgruppe an der exocyclischen N6‐Aminogruppe hin prüfen. Die DNA‐Enzyme erkennen m6A, eine der häufigsten natürlichen RNA‐Modifikationen; zusätzlich führen...
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