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Objective To determine the effective dosage and formulation of agkistrodon in collagen-induced arthritis (CIA) rats. Methods CIA was induced by injection of collagen in complete/incomplete Freund’s adjuvant. Agkistrodon decoction, agkistrodon powder, and agkistrodon wine were administered daily starting from the onset of arthritis. Paw swelling degree was measured by using a volume-measuring instrument...
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