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Kinetics of the metabolic inactivation of 1,2-epoxypropane (propylene oxide; PO) catalyzed by gluathione S-transferase (GST) and by epoxide hydrolase (EH) were investigated at 37 o C in cytosol and microsomes of liver and lung of B6C3F1 mice, F344 rats, and humans and of respiratory and olfactory nasal mucosa of F344 rats. In all of these tissues, GST and EH activities were detected. GST activity...
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